GINS4 [The Human Chemical-Genetic Interaction Map Project]

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======= GINS4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GINS4
  * **<color #00a2e8>Official Name</color>**: GINS complex subunit 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84296|84296]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BRT9|Q9BRT9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GINS4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GINS4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610611|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA. {ECO:0000269|PubMed:17417653}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sld5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GINS complex|
|replication fork protection complex|
|double-strand break repair via break-induced replication|
|inner cell mass cell proliferation|
|DNA strand elongation involved in DNA replication|
|3-5 DNA helicase activity|
|blastocyst growth|
|DNA strand elongation|
|double-strand break repair via homologous recombination|
|blastocyst development|
|recombinational repair|
|DNA duplex unwinding|
|DNA geometric change|
|DNA-dependent DNA replication|
|double-strand break repair|
|DNA replication|
|DNA recombination|
|DNA conformation change|
|in utero embryonic development|
|developmental growth|
|growth|
|DNA repair|
|cell population proliferation|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|embryo development|
|chromosome organization|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.46|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.76|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.72|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.72|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.76|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 597/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|23/28|
|bone|23/26|
|breast|28/33|
|central nervous system|50/56|
|cervix|3/4|
|colorectal|16/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|17/21|
|liver|18/20|
|lung|59/75|
|lymphocyte|11/16|
|ovary|21/26|
|pancreas|22/24|
|peripheral nervous system|16/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|21/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 984
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GINS4 Expression in NALM6 Cells: 6.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>