GINS4

Entrez Summary: N/A
UniProt Summary: The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA. {ECO:0000269|PubMed:17417653}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 597/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	23/28
blood	23/28
bone	23/26
breast	28/33
central nervous system	50/56
cervix	3/4
colorectal	16/17
esophagus	10/13
fibroblast	1/1
gastric	12/16
kidney	17/21
liver	18/20
lung	59/75
lymphocyte	11/16
ovary	21/26
pancreas	22/24
peripheral nervous system	16/16
plasma cell	9/15
prostate	1/1
skin	17/24
soft tissue	6/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	21/29
uterus	3/5

Expression Distribution

GINS complex
replication fork protection complex
double-strand break repair via break-induced replication
inner cell mass cell proliferation
DNA strand elongation involved in DNA replication
3-5 DNA helicase activity
blastocyst growth
DNA strand elongation
double-strand break repair via homologous recombination
blastocyst development
recombinational repair
DNA duplex unwinding
DNA geometric change
DNA-dependent DNA replication
double-strand break repair
DNA replication
DNA recombination
DNA conformation change
in utero embryonic development
developmental growth
growth
DNA repair
cell population proliferation
chordate embryonic development
embryo development ending in birth or egg hatching
DNA metabolic process
cellular response to DNA damage stimulus
embryo development
chromosome organization
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process