GJC1 [The Human Chemical-Genetic Interaction Map Project]

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======= GJC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GJC1
  * **<color #00a2e8>Official Name</color>**: gap junction protein gamma 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10052|10052]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P36383|P36383]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GJC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GJC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608655|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Connexin|
|Connexin CCC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling|
|SA node cell to atrial cardiac muscle cell communication by electrical coupling|
|AV node cell to bundle of His cell communication by electrical coupling|
|gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling|
|gap junction assembly|
|SA node cell to atrial cardiac muscle cell communication|
|AV node cell to bundle of His cell communication|
|atrial cardiac muscle cell to AV node cell signaling|
|atrial cardiac muscle cell action potential|
|atrial cardiac muscle cell to AV node cell communication|
|cell communication by electrical coupling involved in cardiac conduction|
|gap junction|
|cell communication by electrical coupling|
|connexin complex|
|ion channel activity|
|cell-cell signaling involved in cardiac conduction|
|cardiac muscle cell action potential involved in contraction|
|cardiac muscle cell contraction|
|cell communication involved in cardiac conduction|
|intercalated disc|
|cardiac muscle cell action potential|
|vasculogenesis|
|cardiac muscle contraction|
|heart contraction|
|actin-mediated cell contraction|
|cardiac conduction|
|action potential|
|heart process|
|cell-cell junction assembly|
|striated muscle contraction|
|actin filament-based movement|
|multicellular organismal signaling|
|cell-cell junction organization|
|cardiac muscle tissue development|
|cell junction assembly|
|cell junction organization|
|visual perception|
|sensory perception of light stimulus|
|regulation of heart contraction|
|muscle contraction|
|striated muscle tissue development|
|regulation of blood circulation|
|muscle tissue development|
|muscle system process|
|blood circulation|
|circulatory system process|
|blood vessel morphogenesis|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|regulation of membrane potential|
|trans-synaptic signaling|
|synaptic signaling|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|heart development|
|actin filament-based process|
|regulation of system process|
|tube morphogenesis|
|tube development|
|circulatory system development|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|sensory perception|
|cell-cell signaling|
|transmembrane transport|
|ion transport|
|nervous system process|
|movement of cell or subcellular component|
|cell development|
|tissue development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|7.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11923
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GJC1 Expression in NALM6 Cells: 7.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>