GJC1

Entrez Summary: N/A
UniProt Summary: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Connexin
Connexin CCC

gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling
SA node cell to atrial cardiac muscle cell communication by electrical coupling
AV node cell to bundle of His cell communication by electrical coupling
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
gap junction assembly
SA node cell to atrial cardiac muscle cell communication
AV node cell to bundle of His cell communication
atrial cardiac muscle cell to AV node cell signaling
atrial cardiac muscle cell action potential
atrial cardiac muscle cell to AV node cell communication
cell communication by electrical coupling involved in cardiac conduction
gap junction
cell communication by electrical coupling
connexin complex
ion channel activity
cell-cell signaling involved in cardiac conduction
cardiac muscle cell action potential involved in contraction
cardiac muscle cell contraction
cell communication involved in cardiac conduction
intercalated disc
cardiac muscle cell action potential
vasculogenesis
cardiac muscle contraction
heart contraction
actin-mediated cell contraction
cardiac conduction
action potential
heart process
cell-cell junction assembly
striated muscle contraction
actin filament-based movement
multicellular organismal signaling
cell-cell junction organization
cardiac muscle tissue development
cell junction assembly
cell junction organization
visual perception
sensory perception of light stimulus
regulation of heart contraction
muscle contraction