GLG1

Gene Information

Official Symbol: GLG1
Official Name: golgi glycoprotein 1
Aliases and Previous Symbols: N/A
Entrez ID: 2734
UniProt: Q92896
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Binds fibroblast growth factor and E-selectin (cell- adhesion lectin on endothelial cells mediating the binding of neutrophils).

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13627
Expression level (log2 read counts): 9.17

Expression Distribution

fibroblast growth factor binding
negative regulation of protein processing
negative regulation of protein maturation
regulation of chondrocyte differentiation
regulation of protein processing
regulation of protein maturation
regulation of cartilage development
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cellular response to transforming growth factor beta stimulus
bone morphogenesis
regulation of transforming growth factor beta receptor signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of cellular response to growth factor stimulus
bone development
extracellular matrix
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
skeletal system morphogenesis
regulation of cellular response to growth factor stimulus
signaling receptor binding
negative regulation of proteolysis
leukocyte migration
skeletal system development
Golgi membrane
regulation of proteolysis
animal organ morphogenesis
cell migration
Golgi apparatus
negative regulation of cellular protein metabolic process
localization of cell
cell motility
negative regulation of protein metabolic process
negative regulation of signal transduction
locomotion
negative regulation of cell communication
negative regulation of signaling
movement of cell or subcellular component
negative regulation of response to stimulus
negative regulation of gene expression
regulation of cell differentiation