GLI4

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rucaparib 6.5μM R08 exp520	-2.3
Geldanamycin 0.01μM R05 exp235	-1.98
Nicotinate 1000μM R03 exp140	1.71
Vinblastine 0.002μM R01 exp60	1.81
Talazoparib 0.006μM R06 exp299	1.85
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.86
SGC0946 7μM R03 exp151	1.87

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DNA-binding transcription factor activity
molecular function
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific