GLTPD1 [The Human Chemical-Genetic Interaction Map Project]

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======= GLTPD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CPTP
  * **<color #00a2e8>Official Name</color>**: ceramide-1-phosphate transfer protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80772|80772]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5TA50|Q5TA50]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GLTPD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GLTPD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615467|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. {ECO:0000269|PubMed:23863933}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GLTP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glycolipid transport|
|ceramide 1-phosphate binding|
|negative regulation of NLRP3 inflammasome complex assembly|
|ceramide 1-phosphate transport|
|intermembrane lipid transfer|
|ceramide 1-phosphate transfer activity|
|ceramide transport|
|negative regulation of interleukin-1 beta secretion|
|regulation of NLRP3 inflammasome complex assembly|
|negative regulation of interleukin-1 secretion|
|nuclear outer membrane|
|negative regulation of interleukin-1 beta production|
|negative regulation of interleukin-1 production|
|regulation of interleukin-1 beta secretion|
|regulation of interleukin-1 secretion|
|glycosphingolipid metabolic process|
|negative regulation of cytokine secretion|
|carbohydrate derivative transport|
|regulation of interleukin-1 beta production|
|negative regulation of autophagy|
|phospholipid transport|
|regulation of interleukin-1 production|
|phospholipid binding|
|glycolipid metabolic process|
|liposaccharide metabolic process|
|organophosphate ester transport|
|negative regulation of protein complex assembly|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|sphingolipid metabolic process|
|lipid binding|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|membrane lipid metabolic process|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|endosome membrane|
|negative regulation of secretion|
|negative regulation of cellular catabolic process|
|negative regulation of cytokine production|
|lipid transport|
|negative regulation of catabolic process|
|lipid localization|
|regulation of autophagy|
|regulation of protein complex assembly|
|organic anion transport|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|anion transport|
|regulation of cytokine production|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of cellular catabolic process|
|membrane organization|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|Golgi apparatus|
|regulation of catabolic process|
|carbohydrate derivative metabolic process|
|regulation of protein localization|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|ion transport|
|amide transport|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-1.8|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.79|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.74|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.73|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7605
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GLTPD1 Expression in NALM6 Cells: 3.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>