GLTPD1

Entrez Summary: N/A
UniProt Summary: Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. {ECO:0000269|PubMed:23863933}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glycolipid transport
ceramide 1-phosphate binding
negative regulation of NLRP3 inflammasome complex assembly
ceramide 1-phosphate transport
intermembrane lipid transfer
ceramide 1-phosphate transfer activity
ceramide transport
negative regulation of interleukin-1 beta secretion
regulation of NLRP3 inflammasome complex assembly
negative regulation of interleukin-1 secretion
nuclear outer membrane
negative regulation of interleukin-1 beta production
negative regulation of interleukin-1 production
regulation of interleukin-1 beta secretion
regulation of interleukin-1 secretion
glycosphingolipid metabolic process
negative regulation of cytokine secretion
carbohydrate derivative transport
regulation of interleukin-1 beta production
negative regulation of autophagy
phospholipid transport
regulation of interleukin-1 production
phospholipid binding
glycolipid metabolic process
liposaccharide metabolic process
organophosphate ester transport
negative regulation of protein complex assembly
negative regulation of protein secretion
negative regulation of peptide secretion
sphingolipid metabolic process
lipid binding
negative regulation of protein transport
negative regulation of establishment of protein localization
membrane lipid metabolic process
negative regulation of secretion by cell
regulation of cytokine secretion
endosome membrane
negative regulation of secretion
negative regulation of cellular catabolic process
negative regulation of cytokine production