GNA11 [The Human Chemical-Genetic Interaction Map Project]

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======= GNA11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GNA11
  * **<color #00a2e8>Official Name</color>**: G protein subunit alpha 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2767|2767]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29992|P29992]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GNA11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GNA11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/139313|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|G-alpha|
|Arf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|type 2A serotonin receptor binding|
|regulation of melanocyte differentiation|
|phospholipase C-activating dopamine receptor signaling pathway|
|regulation of pigment cell differentiation|
|regulation of developmental pigmentation|
|phototransduction, visible light|
|G protein-coupled acetylcholine receptor signaling pathway|
|G-protein beta/gamma-subunit complex binding|
|cellular response to pH|
|entrainment of circadian clock|
|acetylcholine receptor signaling pathway|
|heterotrimeric G-protein complex|
|cellular response to acetylcholine|
|response to acetylcholine|
|dopamine receptor signaling pathway|
|postsynaptic signal transduction|
|response to pH|
|developmental pigmentation|
|phototransduction|
|detection of visible light|
|photoreceptor outer segment|
|detection of light stimulus|
|G protein-coupled receptor binding|
|cellular response to dopamine|
|response to dopamine|
|pigmentation|
|signal transduction involved in cellular response to ammonium ion|
|action potential|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|cellular response to monoamine stimulus|
|cellular response to catecholamine stimulus|
|response to monoamine|
|response to catecholamine|
|regulation of circadian rhythm|
|detection of external stimulus|
|detection of abiotic stimulus|
|cellular response to ammonium ion|
|platelet activation|
|response to ammonium ion|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|blood coagulation|
|coagulation|
|hemostasis|
|lysosomal membrane|
|response to light stimulus|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|GTPase activity|
|GTP binding|
|cellular response to drug|
|regulation of membrane potential|
|response to radiation|
|synaptic signaling|
|wound healing|
|skeletal system development|
|regulation of body fluid levels|
|heart development|
|cellular response to organic cyclic compound|
|response to wounding|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|detection of stimulus|
|circulatory system development|
|response to hormone|
|response to organic cyclic compound|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|cell-cell signaling|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.74|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.7|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|1.71|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.72|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.78|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.05|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.51|
|[[:results:exp136|MS094 2μM R03 exp136]]|2.69|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5433
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GNA11 Expression in NALM6 Cells: 4.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>