GNA11

Entrez Summary: The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013].
UniProt Summary: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
WNT3A 44ng/ml R08 exp537	-1.74
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.7
Alda-1 10μM R06 exp262	1.71
A-366 10μM R03 exp115	1.72
Dimethyloxaloylglycine 100μM R05 exp229	1.78
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.05
Trientine 500μM R08 exp534	2.51
MS094 2μM R03 exp136	2.69

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

G-alpha
Arf

type 2A serotonin receptor binding
regulation of melanocyte differentiation
phospholipase C-activating dopamine receptor signaling pathway
regulation of pigment cell differentiation
regulation of developmental pigmentation
phototransduction, visible light
G protein-coupled acetylcholine receptor signaling pathway
G-protein beta/gamma-subunit complex binding
cellular response to pH
entrainment of circadian clock
acetylcholine receptor signaling pathway
heterotrimeric G-protein complex
cellular response to acetylcholine
response to acetylcholine
dopamine receptor signaling pathway
postsynaptic signal transduction
response to pH
developmental pigmentation
phototransduction
detection of visible light
photoreceptor outer segment
detection of light stimulus
G protein-coupled receptor binding
cellular response to dopamine
response to dopamine
pigmentation
signal transduction involved in cellular response to ammonium ion
action potential
phospholipase C-activating G protein-coupled receptor signaling pathway
cellular response to monoamine stimulus
cellular response to catecholamine stimulus
response to monoamine
response to catecholamine
regulation of circadian rhythm
detection of external stimulus
detection of abiotic stimulus
cellular response to ammonium ion
platelet activation
response to ammonium ion
adenylate cyclase-modulating G protein-coupled receptor signaling pathway