GNAO1

Entrez Summary: The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015].
UniProt Summary: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Arf
G-alpha

mu-type opioid receptor binding
G protein-coupled serotonin receptor binding
corticotropin-releasing hormone receptor 1 binding
GTPase activating protein binding
G-protein beta/gamma-subunit complex binding
heterotrimeric G-protein complex
myelin sheath
response to isoquinoline alkaloid
response to morphine
dopamine receptor signaling pathway
Wnt signaling pathway, calcium modulating pathway
negative regulation of calcium ion transport
G protein-coupled receptor binding
cell body
response to anesthetic
odontogenesis of dentin-containing tooth
cellular response to dopamine
response to dopamine
signal transduction involved in cellular response to ammonium ion
cellular response to catecholamine stimulus
cellular response to monoamine stimulus
response to monoamine
response to catecholamine
response to alkaloid
response to hydrogen peroxide
odontogenesis
cellular response to ammonium ion
non-canonical Wnt signaling pathway
negative regulation of ion transport
response to ammonium ion
response to reactive oxygen species
locomotory behavior
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
protein folding
regulation of heart contraction
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
regulation of calcium ion transport
muscle contraction
aging
regulation of blood circulation