GOLGA4

Gene Information

Official Symbol: GOLGA4
Official Name: golgin A4
Aliases and Previous Symbols: N/A
Entrez ID: 2803
UniProt: Q13439
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010].
UniProt Summary: Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:29084197}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15063
Expression level (log2 read counts): 5.83

Expression Distribution

Screen	Score
Dorsomorphin 5μM R07 exp357	-1.94
Isoniazid 100μM R08 exp494	-1.78

Golgi to plasma membrane protein transport
GTPase binding
positive regulation of axon extension
establishment of protein localization to plasma membrane
Golgi to plasma membrane transport
positive regulation of axonogenesis
vesicle-mediated transport to the plasma membrane
regulation of axon extension
post-Golgi vesicle-mediated transport
regulation of extent of cell growth
positive regulation of cell morphogenesis involved in differentiation
positive regulation of cell growth
trans-Golgi network
positive regulation of developmental growth
regulation of cell size
protein localization to plasma membrane
regulation of axonogenesis
protein localization to cell periphery
positive regulation of growth
establishment of protein localization to membrane
positive regulation of neuron projection development
regulation of cell morphogenesis involved in differentiation
regulation of developmental growth
positive regulation of neuron differentiation
Golgi vesicle transport
regulation of cellular component size
positive regulation of cell projection organization
regulation of cell growth
positive regulation of neurogenesis
protein localization to membrane
regulation of cell morphogenesis
regulation of neuron projection development
regulation of anatomical structure size
positive regulation of nervous system development
positive regulation of cell development
Golgi membrane
regulation of neuron differentiation
regulation of growth
intracellular membrane-bounded organelle
regulation of plasma membrane bounded cell projection organization