GPC1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= GPC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPC1
  * **<color #00a2e8>Official Name</color>**: glypican 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2817|2817]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35052|P35052]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600395|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. {ECO:0000250, ECO:0000269|PubMed:19936054, ECO:0000269|PubMed:21642435}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glypican|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|heparan sulfate proteoglycan catabolic process|
|proteoglycan catabolic process|
|positive regulation of skeletal muscle cell differentiation|
|negative regulation of fibroblast growth factor receptor signaling pathway|
|regulation of skeletal muscle cell differentiation|
|myelin assembly|
|glycoprotein catabolic process|
|fibroblast growth factor binding|
|laminin binding|
|positive regulation of skeletal muscle tissue development|
|regulation of fibroblast growth factor receptor signaling pathway|
|anchored component of plasma membrane|
|heparan sulfate proteoglycan metabolic process|
|Schwann cell differentiation|
|intrinsic component of plasma membrane|
|regulation of skeletal muscle tissue development|
|copper ion binding|
|glycosaminoglycan catabolic process|
|aminoglycan catabolic process|
|positive regulation of muscle organ development|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle tissue development|
|peripheral nervous system development|
|proteoglycan metabolic process|
|lysosomal lumen|
|Golgi lumen|
|cellular component assembly involved in morphogenesis|
|retinoid metabolic process|
|glycosaminoglycan biosynthetic process|
|myelination|
|aminoglycan biosynthetic process|
|ensheathment of neurons|
|axon ensheathment|
|diterpenoid metabolic process|
|terpenoid metabolic process|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|isoprenoid metabolic process|
|negative regulation of cellular response to growth factor stimulus|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|glial cell differentiation|
|regulation of protein localization to membrane|
|carbohydrate derivative catabolic process|
|gliogenesis|
|membrane raft|
|extracellular matrix|
|axon guidance|
|neuron projection guidance|
|synapse|
|endosome|
|regulation of cellular response to growth factor stimulus|
|collagen-containing extracellular matrix|
|axonogenesis|
|leukocyte migration|
|glycoprotein metabolic process|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|regulation of cellular protein localization|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|cell surface|
|carbohydrate derivative biosynthetic process|
|neuron projection development|
|protein catabolic process|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|anatomical structure formation involved in morphogenesis|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|cellular lipid metabolic process|
|cell migration|
|positive regulation of cell differentiation|
|neuron differentiation|
|carbohydrate derivative metabolic process|
|regulation of protein localization|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|localization of cell|
|cell motility|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|lipid metabolic process|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|generation of neurons|
|movement of cell or subcellular component|
|extracellular space|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-2.05|
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.71|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10032
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.38 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPC1 Expression in NALM6 Cells: -2.38'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>