GPC1

Entrez Summary: N/A
UniProt Summary: Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. {ECO:0000250, ECO:0000269|PubMed:19936054, ECO:0000269|PubMed:21642435}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

heparan sulfate proteoglycan catabolic process
proteoglycan catabolic process
positive regulation of skeletal muscle cell differentiation
negative regulation of fibroblast growth factor receptor signaling pathway
regulation of skeletal muscle cell differentiation
myelin assembly
glycoprotein catabolic process
fibroblast growth factor binding
laminin binding
positive regulation of skeletal muscle tissue development
regulation of fibroblast growth factor receptor signaling pathway
anchored component of plasma membrane
heparan sulfate proteoglycan metabolic process
Schwann cell differentiation
intrinsic component of plasma membrane
regulation of skeletal muscle tissue development
copper ion binding
glycosaminoglycan catabolic process
aminoglycan catabolic process
positive regulation of muscle organ development
positive regulation of striated muscle tissue development
positive regulation of muscle tissue development
peripheral nervous system development
proteoglycan metabolic process
lysosomal lumen
Golgi lumen
cellular component assembly involved in morphogenesis
retinoid metabolic process
glycosaminoglycan biosynthetic process
myelination
aminoglycan biosynthetic process
ensheathment of neurons
axon ensheathment
diterpenoid metabolic process
terpenoid metabolic process
regulation of striated muscle tissue development
regulation of muscle tissue development
regulation of muscle organ development
isoprenoid metabolic process
negative regulation of cellular response to growth factor stimulus