GPM6A [The Human Chemical-Genetic Interaction Map Project]

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======= GPM6A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPM6A
  * **<color #00a2e8>Official Name</color>**: glycoprotein M6A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2823|2823]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51674|P51674]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPM6A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPM6A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601275|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G- protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. {ECO:0000269|PubMed:19298174}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myelin PLP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integral component of presynaptic active zone membrane|
|axonal growth cone|
|positive regulation of filopodium assembly|
|regulation of filopodium assembly|
|calcium channel activity|
|extracellular vesicle|
|neural retina development|
|filopodium|
|synapse assembly|
|positive regulation of plasma membrane bounded cell projection assembly|
|neuron migration|
|retina development in camera-type eye|
|dendritic spine|
|stem cell differentiation|
|calcium ion transmembrane transport|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|calcium ion transport|
|synapse organization|
|divalent metal ion transport|
|divalent inorganic cation transport|
|camera-type eye development|
|neuron projection|
|glutamatergic synapse|
|eye development|
|visual system development|
|sensory system development|
|neuronal cell body|
|positive regulation of cell projection organization|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|positive regulation of cellular component biogenesis|
|sensory organ development|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|neuron projection development|
|response to bacterium|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|cation transport|
|ion transmembrane transport|
|regulation of cellular component biogenesis|
|cell migration|
|neuron differentiation|
|localization of cell|
|cell motility|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|transmembrane transport|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|ion transport|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8249
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPM6A Expression in NALM6 Cells: 1.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>