GPM6A

Entrez Summary: N/A
UniProt Summary: Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G- protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. {ECO:0000269|PubMed:19298174}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

integral component of presynaptic active zone membrane
axonal growth cone
positive regulation of filopodium assembly
regulation of filopodium assembly
calcium channel activity
extracellular vesicle
neural retina development
filopodium
synapse assembly
positive regulation of plasma membrane bounded cell projection assembly
neuron migration
retina development in camera-type eye
dendritic spine
stem cell differentiation
calcium ion transmembrane transport
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
regulation of synapse organization
regulation of synapse structure or activity
calcium ion transport
synapse organization
divalent metal ion transport
divalent inorganic cation transport
camera-type eye development
neuron projection
glutamatergic synapse
eye development
visual system development
sensory system development
neuronal cell body
positive regulation of cell projection organization
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
positive regulation of cellular component biogenesis
sensory organ development
inorganic cation transmembrane transport
cation transmembrane transport
metal ion transport