GPM6B

Entrez Summary: This gene encodes a membrane glycoprotein that belongs to the proteolipid protein family. Proteolipid protein family members are expressed in most brain regions and are thought to be involved in cellular housekeeping functions such as membrane trafficking and cell-to-cell communication. This protein may also be involved in osteoblast differentiation. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes Y and 22. [provided by RefSeq, Jan 2016].
UniProt Summary: May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake. {ECO:0000269|PubMed:21638316}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
GSK591 2.6μM R03 exp128	1.79
Genistein 15μM R07 exp360	1.8

negative regulation of serotonin uptake
regulation of serotonin uptake
negative regulation of neurotransmitter uptake
negative regulation of protein localization to cell surface
regulation of neurotransmitter uptake
extracellular matrix assembly
negative regulation of neurotransmitter transport
regulation of protein localization to cell surface
positive regulation of bone mineralization
positive regulation of biomineralization
positive regulation of biomineral tissue development
regulation of cell-substrate junction assembly
regulation of focal adhesion assembly
regulation of adherens junction organization
regulation of bone mineralization
positive regulation of ossification
regulation of cell junction assembly
regulation of biomineral tissue development
regulation of biomineralization
negative regulation of cellular protein localization
regulation of cell-matrix adhesion
regulation of neurotransmitter transport
negative regulation of ion transport
regulation of ossification
regulation of cell-substrate adhesion
membrane raft
ossification
extracellular matrix organization
regulation of actin cytoskeleton organization
regulation of neurotransmitter levels
extracellular structure organization
regulation of actin filament-based process
negative regulation of transport
regulation of cellular protein localization
regulation of cytoskeleton organization
neuron projection development
regulation of cell adhesion
regulation of ion transport
molecular function
neuron development