GPR157

Entrez Summary: N/A
UniProt Summary: Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger. {ECO:0000250|UniProtKB:Q8C206}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cryptotanshinone 12μM R05 exp227	-1.8
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.8
I-BRD9 4μM R07 exp365	-1.72
Bisphenol S 100μM R08 exp458	1.78
CB-839 10μM R05 exp224	1.92
Talazoparib 0.006μM R06 exp299	1.96

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

radial glial cell differentiation
circadian behavior
rhythmic behavior
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
ciliary membrane
phospholipase C-activating G protein-coupled receptor signaling pathway
circadian rhythm
glial cell differentiation
gliogenesis
rhythmic process
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
cellular metal ion homeostasis
behavior
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
cation homeostasis
inorganic ion homeostasis
G protein-coupled receptor activity
cellular chemical homeostasis
ion homeostasis
cellular homeostasis
chemical homeostasis
G protein-coupled receptor signaling pathway
neurogenesis
homeostatic process