GPR35

Gene Information

Official Symbol: GPR35
Official Name: G protein-coupled receptor 35
Aliases and Previous Symbols: N/A
Entrez ID: 2859
UniProt: Q9HC97
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins. {ECO:0000269|PubMed:16754668}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7564
Expression level (log2 read counts): 1.16

Expression Distribution

negative regulation of neuronal action potential
regulation of neuronal action potential
negative regulation of transmission of nerve impulse
C-X-C chemokine receptor activity
negative regulation of action potential
negative regulation of voltage-gated calcium channel activity
regulation of transmission of nerve impulse
negative regulation of nervous system process
positive regulation of Rho protein signal transduction
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
regulation of voltage-gated calcium channel activity
negative regulation of calcium ion transmembrane transporter activity
negative regulation of calcium ion transmembrane transport
negative regulation of cation channel activity
regulation of action potential
negative regulation of calcium ion transport
positive regulation of Ras protein signal transduction
positive regulation of small GTPase mediated signal transduction
negative regulation of ion transmembrane transporter activity
negative regulation of transporter activity
chemokine-mediated signaling pathway
negative regulation of cation transmembrane transport
regulation of calcium ion transmembrane transporter activity
cellular response to chemokine
response to chemokine
negative regulation of ion transmembrane transport
phospholipase C-activating G protein-coupled receptor signaling pathway
negative regulation of transmembrane transport
regulation of nervous system process
regulation of Rho protein signal transduction
regulation of calcium ion transmembrane transport
negative regulation of ion transport
regulation of cation channel activity
regulation of Ras protein signal transduction
regulation of calcium ion transport
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
regulation of transporter activity
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration