GPR37L1
Gene Information
- Official Symbol: GPR37L1
- Official Name: G protein-coupled receptor 37 like 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 9283
- UniProt: O60883
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade. {ECO:0000269|PubMed:23690594}.
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
GO Terms
| prosaposin receptor activity |
| positive regulation of cerebellar granule cell precursor proliferation |
| regulation of cerebellar granule cell precursor proliferation |
| negative regulation of astrocyte differentiation |
| negative regulation of hydrogen peroxide-induced cell death |
| negative regulation of response to reactive oxygen species |
| negative regulation of systemic arterial blood pressure |
| negative regulation of cellular response to drug |
| regulation of hydrogen peroxide-induced cell death |
| negative regulation of glial cell differentiation |
| regulation of astrocyte differentiation |
| negative regulation of response to drug |
| negative regulation of smoothened signaling pathway |
| regulation of response to reactive oxygen species |
| regulation of cellular response to drug |
| G protein-coupled peptide receptor activity |
| negative regulation of gliogenesis |
| negative regulation of blood pressure |
| negative regulation of oxidative stress-induced cell death |
| negative regulation of cellular response to oxidative stress |
| negative regulation of response to oxidative stress |
| peptide binding |
| positive regulation of neural precursor cell proliferation |
| ciliary membrane |
| regulation of oxidative stress-induced cell death |
| regulation of glial cell differentiation |
| regulation of cellular response to oxidative stress |
| regulation of smoothened signaling pathway |
| adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| regulation of response to oxidative stress |
| regulation of neural precursor cell proliferation |
| regulation of systemic arterial blood pressure |
| regulation of response to drug |
| regulation of gliogenesis |
| regulation of blood pressure |
| receptor complex |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| negative regulation of neuron differentiation |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| negative regulation of neurogenesis |
| negative regulation of nervous system development |
| negative regulation of cell development |
| blood circulation |
| circulatory system process |
| positive regulation of nervous system development |
| positive regulation of MAPK cascade |
| regulation of neuron differentiation |
| negative regulation of cell differentiation |
| G protein-coupled receptor activity |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| regulation of neurogenesis |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| negative regulation of cell death |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| G protein-coupled receptor signaling pathway |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| regulation of protein phosphorylation |
| regulation of response to stress |
| generation of neurons |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Metformin 40μM R03 exp132 | -1.74 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12161
- Expression level (log2 read counts): 2.09
Expression Distribution
GPR37L1 Expression in NALM6 Cells: 2.09
