GPRC5A

Gene Information

Official Symbol: GPRC5A
Official Name: G protein-coupled receptor class C group 5 member A
Aliases and Previous Symbols: N/A
Entrez ID: 9052
UniProt: Q8NFJ5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218). {ECO:0000250|UniProtKB:Q8BHL4, ECO:0000269|PubMed:18000218}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11448
Expression level (log2 read counts): 2.47

Expression Distribution

Screen	Score
Trichostatin-A 0.06μM R07 exp415	-2.25
Rotenone 2μM R00 exp33	-1.92
CyclicAMP 200μM R08 exp475	-1.83
NFN1 1μM R03 exp100	1.7

negative regulation of epidermal growth factor-activated receptor activity
protein kinase activator activity
regulation of epidermal growth factor-activated receptor activity
negative regulation of protein tyrosine kinase activity
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of peptidyl-tyrosine phosphorylation
negative regulation of ERBB signaling pathway
negative regulation of signaling receptor activity
regulation of epidermal growth factor receptor signaling pathway
regulation of protein tyrosine kinase activity
regulation of ERBB signaling pathway
vesicle
cytoplasmic vesicle membrane
regulation of signaling receptor activity
receptor complex
negative regulation of protein kinase activity
negative regulation of kinase activity
regulation of peptidyl-tyrosine phosphorylation
negative regulation of transferase activity
cadherin binding
activation of protein kinase activity
negative regulation of protein phosphorylation
negative regulation of phosphorylation
positive regulation of protein kinase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
positive regulation of kinase activity
negative regulation of protein modification process
positive regulation of transferase activity
intracellular membrane-bounded organelle
G protein-coupled receptor activity
negative regulation of catalytic activity
regulation of protein kinase activity
nucleolus
regulation of kinase activity
regulation of transferase activity
positive regulation of protein phosphorylation
negative regulation of cellular protein metabolic process
positive regulation of phosphorylation
negative regulation of protein metabolic process