GPT

Entrez Summary: This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009].
UniProt Summary: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
PRIM1	0.443
DTL	0.4

L-alanine:2-oxoglutarate aminotransferase activity
L-alanine catabolic process
L-alanine metabolic process
alanine metabolic process
alanine catabolic process
pyruvate family amino acid metabolic process
pyruvate family amino acid catabolic process
pyridoxal phosphate binding
cellular amino acid biosynthetic process
alpha-amino acid catabolic process
cellular amino acid catabolic process
alpha-amino acid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
small molecule catabolic process
small molecule biosynthetic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound catabolic process
organonitrogen compound biosynthetic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process