GPX3

Entrez Summary: N/A
UniProt Summary: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

response to lipid hydroperoxide
selenium binding
response to hydroperoxide
glutathione peroxidase activity
hydrogen peroxide catabolic process
peroxidase activity
hydrogen peroxide metabolic process
antibiotic catabolic process
cofactor catabolic process
cellular oxidant detoxification
protein homotetramerization
cellular detoxification
antibiotic metabolic process
reactive oxygen species metabolic process
detoxification
drug catabolic process
protein tetramerization
cellular response to toxic substance
cellular response to oxidative stress
transcription factor binding
protein homooligomerization
response to oxidative stress
cofactor metabolic process
drug metabolic process
response to toxic substance
protein complex oligomerization
oxidation-reduction process
response to oxygen-containing compound
protein-containing complex assembly
extracellular space
cellular response to stress
cellular catabolic process
protein-containing complex subunit organization
extracellular region