GRAP2

Entrez Summary: N/A
UniProt Summary: Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SH3/SH2 adaptor activity
T cell costimulation
lymphocyte costimulation
Fc-epsilon receptor signaling pathway
T cell receptor signaling pathway
positive regulation of T cell activation
positive regulation of leukocyte cell-cell adhesion
Fc receptor signaling pathway
Ras protein signal transduction
positive regulation of cell-cell adhesion
endosome
antigen receptor-mediated signaling pathway
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
small GTPase mediated signal transduction
positive regulation of lymphocyte activation
regulation of cell-cell adhesion
positive regulation of leukocyte activation
positive regulation of cell adhesion
positive regulation of cell activation
immune response-activating cell surface receptor signaling pathway
immune response-regulating cell surface receptor signaling pathway
regulation of lymphocyte activation
immune response-activating signal transduction
immune response-regulating signaling pathway
regulation of leukocyte activation
activation of immune response
regulation of cell activation
regulation of cell adhesion
positive regulation of immune response
cell-cell signaling
regulation of immune response
positive regulation of immune system process
regulation of immune system process
positive regulation of signal transduction
intracellular signal transduction
positive regulation of cell communication
positive regulation of signaling