GRIA4
Gene Information
- Official Symbol: GRIA4
- Official Name: glutamate ionotropic receptor AMPA type subunit 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 2893
- UniProt: P48058
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO:0000269|PubMed:21172611}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12825
- Expression level (log2 read counts): 1.52
GRIA4 Expression in NALM6 Cells: 1.52
