GRID1

Entrez Summary: This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009].
UniProt Summary: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ionotropic glutamate receptor activity
glutamate receptor activity
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
glutamate receptor signaling pathway
integral component of postsynaptic density membrane
social behavior
intraspecies interaction between organisms
multi-organism behavior
regulation of postsynaptic membrane potential
postsynaptic membrane
glutamatergic synapse
anterograde trans-synaptic signaling
chemical synaptic transmission
regulation of membrane potential
trans-synaptic signaling
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
synaptic signaling
cell junction
behavior
ion transmembrane transport
cell-cell signaling
transmembrane transport
ion transport