GRIN2C [The Human Chemical-Genetic Interaction Map Project]

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======= GRIN2C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRIN2C
  * **<color #00a2e8>Official Name</color>**: glutamate ionotropic receptor NMDA type subunit 2C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2905|2905]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14957|Q14957]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRIN2C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRIN2C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138254|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:26875626). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). {ECO:0000250|UniProtKB:Q01098, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:28095420, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lig chan|
|ANF receptor|
|Lig chan-Glu bd|
|SBP bac 3|
|NMDAR2 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|directional locomotion|
|glutamate-gated calcium ion channel activity|
|NMDA glutamate receptor activity|
|excitatory chemical synaptic transmission|
|NMDA selective glutamate receptor complex|
|postsynaptic density membrane|
|ionotropic glutamate receptor signaling pathway|
|protein localization to postsynaptic membrane|
|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential|
|glutamate receptor signaling pathway|
|long-term synaptic potentiation|
|neuromuscular process controlling balance|
|excitatory postsynaptic potential|
|protein localization to synapse|
|chemical synaptic transmission, postsynaptic|
|calcium ion transmembrane import into cytosol|
|calcium ion transport into cytosol|
|cytosolic calcium ion transport|
|regulation of postsynaptic membrane potential|
|neuromuscular process|
|negative regulation of protein catabolic process|
|calcium-mediated signaling|
|positive regulation of synaptic transmission|
|regulation of synaptic plasticity|
|calcium ion transmembrane transport|
|protein localization to cell periphery|
|calcium ion transport|
|positive regulation of cytosolic calcium ion concentration|
|divalent metal ion transport|
|divalent inorganic cation transport|
|negative regulation of catabolic process|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|glutamatergic synapse|
|regulation of protein catabolic process|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|protein localization to membrane|
|divalent inorganic cation homeostasis|
|cell junction|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|response to wounding|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cation homeostasis|
|inorganic ion homeostasis|
|brain development|
|cellular chemical homeostasis|
|head development|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|central nervous system development|
|regulation of catabolic process|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|cell-cell signaling|
|transmembrane transport|
|locomotion|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|cellular protein localization|
|cellular macromolecule localization|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3942
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRIN2C Expression in NALM6 Cells: 1.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>