GRIN2C

Gene Information

Official Symbol: GRIN2C
Official Name: glutamate ionotropic receptor NMDA type subunit 2C
Aliases and Previous Symbols: N/A
Entrez ID: 2905
UniProt: Q14957
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:26875626). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). {ECO:0000250|UniProtKB:Q01098, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:28095420, ECO:0000305}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3942
Expression level (log2 read counts): 1.67

Expression Distribution

Lig chan
ANF receptor
Lig chan-Glu bd
SBP bac 3
NMDAR2 C

directional locomotion
glutamate-gated calcium ion channel activity
NMDA glutamate receptor activity
excitatory chemical synaptic transmission
NMDA selective glutamate receptor complex
postsynaptic density membrane
ionotropic glutamate receptor signaling pathway
protein localization to postsynaptic membrane
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
glutamate receptor signaling pathway
long-term synaptic potentiation
neuromuscular process controlling balance
excitatory postsynaptic potential
protein localization to synapse
chemical synaptic transmission, postsynaptic
calcium ion transmembrane import into cytosol
calcium ion transport into cytosol
cytosolic calcium ion transport
regulation of postsynaptic membrane potential
neuromuscular process
negative regulation of protein catabolic process
calcium-mediated signaling
positive regulation of synaptic transmission
regulation of synaptic plasticity
calcium ion transmembrane transport
protein localization to cell periphery
calcium ion transport
positive regulation of cytosolic calcium ion concentration
divalent metal ion transport
divalent inorganic cation transport
negative regulation of catabolic process
regulation of cytosolic calcium ion concentration
second-messenger-mediated signaling
glutamatergic synapse
regulation of protein catabolic process
anterograde trans-synaptic signaling
chemical synaptic transmission
cell surface receptor signaling pathway involved in cell-cell signaling
regulation of membrane potential
cellular calcium ion homeostasis