GRIP1 [The Human Chemical-Genetic Interaction Map Project]

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======= GRIP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRIP1
  * **<color #00a2e8>Official Name</color>**: glutamate receptor interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23426|23426]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3R0|Q9Y3R0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRIP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRIP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604597|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). {ECO:0000250|UniProtKB:P97879, ECO:0000269|PubMed:10197531}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of neuron projection arborization|
|neurotransmitter receptor transport, endosome to postsynaptic membrane|
|regulation of neuron projection arborization|
|neurotransmitter receptor transport, endosome to plasma membrane|
|endosome to plasma membrane protein transport|
|glucocorticoid receptor binding|
|neurotransmitter receptor transport to plasma membrane|
|neurotransmitter receptor transport to postsynaptic membrane|
|establishment of protein localization to postsynaptic membrane|
|receptor signaling complex adaptor activity|
|retrograde transport, endosome to plasma membrane|
|protein localization to postsynaptic membrane|
|neurotransmitter receptor transport|
|androgen receptor signaling pathway|
|receptor localization to synapse|
|androgen receptor binding|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|establishment of protein localization to plasma membrane|
|protein localization to synapse|
|intracellular steroid hormone receptor signaling pathway|
|beta-catenin binding|
|vesicle-mediated transport to the plasma membrane|
|dendrite development|
|steroid hormone mediated signaling pathway|
|vesicle-mediated transport in synapse|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|protein localization to plasma membrane|
|cellular response to steroid hormone stimulus|
|protein C-terminus binding|
|postsynaptic membrane|
|membrane raft|
|protein localization to cell periphery|
|endosomal transport|
|cytoplasmic vesicle|
|protein-containing complex localization|
|establishment of protein localization to membrane|
|positive regulation of neuron projection development|
|transcription coactivator activity|
|neuron projection|
|response to steroid hormone|
|glutamatergic synapse|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|positive regulation of neurogenesis|
|protein localization to membrane|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cellular response to lipid|
|positive regulation of nervous system development|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|cell junction|
|cellular response to hormone stimulus|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|neuron development|
|regulation of neurogenesis|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|intracellular protein transport|
|endoplasmic reticulum|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of developmental process|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14618
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRIP1 Expression in NALM6 Cells: 1.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>