GRIP1

Gene Information

Official Symbol: GRIP1
Official Name: glutamate receptor interacting protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 23426
UniProt: Q9Y3R0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010].
UniProt Summary: May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). {ECO:0000250|UniProtKB:P97879, ECO:0000269|PubMed:10197531}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14618
Expression level (log2 read counts): 1.78

Expression Distribution

positive regulation of neuron projection arborization
neurotransmitter receptor transport, endosome to postsynaptic membrane
regulation of neuron projection arborization
neurotransmitter receptor transport, endosome to plasma membrane
endosome to plasma membrane protein transport
glucocorticoid receptor binding
neurotransmitter receptor transport to plasma membrane
neurotransmitter receptor transport to postsynaptic membrane
establishment of protein localization to postsynaptic membrane
receptor signaling complex adaptor activity
retrograde transport, endosome to plasma membrane
protein localization to postsynaptic membrane
neurotransmitter receptor transport
androgen receptor signaling pathway
receptor localization to synapse
androgen receptor binding
regulation of postsynaptic membrane neurotransmitter receptor levels
establishment of protein localization to plasma membrane
protein localization to synapse
intracellular steroid hormone receptor signaling pathway
beta-catenin binding
vesicle-mediated transport to the plasma membrane
dendrite development
steroid hormone mediated signaling pathway
vesicle-mediated transport in synapse
intracellular receptor signaling pathway
hormone-mediated signaling pathway
protein localization to plasma membrane
cellular response to steroid hormone stimulus
protein C-terminus binding
postsynaptic membrane
membrane raft
protein localization to cell periphery
endosomal transport
cytoplasmic vesicle
protein-containing complex localization
establishment of protein localization to membrane
positive regulation of neuron projection development
transcription coactivator activity
neuron projection