GRPEL2

Entrez Summary: N/A
UniProt Summary: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PAM complex, Tim23 associated import motor
adenyl-nucleotide exchange factor activity
protein import into mitochondrial matrix
protein transmembrane import into intracellular organelle
intracellular protein transmembrane transport
protein targeting to mitochondrion
protein transmembrane transport
establishment of protein localization to mitochondrion
protein localization to mitochondrion
mitochondrial transmembrane transport
chaperone binding
unfolded protein binding
protein import
mitochondrial transport
protein folding
protein targeting
establishment of protein localization to organelle
mitochondrion organization
protein localization to organelle
protein homodimerization activity
intracellular protein transport
mitochondrion
transmembrane transport
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport