GRWD1 [The Human Chemical-Genetic Interaction Map Project]

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======= GRWD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRWD1
  * **<color #00a2e8>Official Name</color>**: glutamate rich WD repeat containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83743|83743]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BQ67|Q9BQ67]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRWD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRWD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610597|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725). {ECO:0000269|PubMed:25990725}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CAF1C H4-bd|
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chromatin disassembly|
|nucleosome disassembly|
|protein-DNA complex disassembly|
|DNA replication origin binding|
|nucleosome assembly|
|chromosome|
|histone binding|
|chromatin assembly|
|chromatin assembly or disassembly|
|nucleosome organization|
|DNA packaging|
|protein-DNA complex assembly|
|DNA replication|
|protein-containing complex disassembly|
|protein-DNA complex subunit organization|
|DNA conformation change|
|chromatin binding|
|cellular component disassembly|
|protein-containing complex|
|chromatin organization|
|cellular protein-containing complex assembly|
|nucleolus|
|chromosome organization|
|RNA binding|
|protein-containing complex assembly|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.72|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 416/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|16/28|
|blood|10/28|
|bone|12/26|
|breast|14/33|
|central nervous system|29/56|
|cervix|1/4|
|colorectal|12/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|7/16|
|kidney|15/21|
|liver|8/20|
|lung|37/75|
|lymphocyte|7/16|
|ovary|17/26|
|pancreas|15/24|
|peripheral nervous system|9/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|14/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|12/22|
|urinary tract|17/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 663
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRWD1 Expression in NALM6 Cells: 6.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>