GRWD1

Gene Information
  • Official Symbol: GRWD1
  • Official Name: glutamate rich WD repeat containing 1
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 83743
  • UniProt: Q9BQ67
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012].
  • UniProt Summary: Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725). {ECO:0000269|PubMed:25990725}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 663
  • Expression level (log2 read counts): 6.32

Expression Distribution

  • Last modified: 2025/12/10 20:19
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