GSTO1 [The Human Chemical-Genetic Interaction Map Project]

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======= GSTO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GSTO1
  * **<color #00a2e8>Official Name</color>**: glutathione S-transferase omega 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9446|9446]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78417|P78417]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GSTO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GSTO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605482|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. {ECO:0000269|PubMed:10783391, ECO:0000269|PubMed:11511179, ECO:0000269|PubMed:17226937, ECO:0000269|PubMed:18028863, ECO:0000269|PubMed:21106529}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GST C|
|GST N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion|
|methylarsonate reductase activity|
|glutathione dehydrogenase (ascorbate) activity|
|regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion|
|regulation of skeletal muscle contraction by calcium ion signaling|
|positive regulation of ryanodine-sensitive calcium-release channel activity|
|L-ascorbic acid metabolic process|
|negative regulation of ryanodine-sensitive calcium-release channel activity|
|xenobiotic catabolic process|
|regulation of skeletal muscle contraction|
|negative regulation of release of sequestered calcium ion into cytosol|
|positive regulation of striated muscle contraction|
|positive regulation of sequestering of calcium ion|
|negative regulation of calcium ion transport into cytosol|
|cellular response to arsenic-containing substance|
|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|
|glutathione derivative biosynthetic process|
|glutathione derivative metabolic process|
|regulation of cardiac muscle contraction by calcium ion signaling|
|regulation of ryanodine-sensitive calcium-release channel activity|
|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|glutathione transferase activity|
|negative regulation of calcium-mediated signaling|
|response to arsenic-containing substance|
|negative regulation of calcium ion transmembrane transporter activity|
|negative regulation of calcium ion transmembrane transport|
|positive regulation of calcium ion transmembrane transporter activity|
|positive regulation of release of sequestered calcium ion into cytosol|
|negative regulation of cation channel activity|
|positive regulation of calcium-mediated signaling|
|positive regulation of muscle contraction|
|interleukin-12-mediated signaling pathway|
|cellular response to interleukin-12|
|response to interleukin-12|
|positive regulation of calcium ion transport into cytosol|
|negative regulation of calcium ion transport|
|positive regulation of cation channel activity|
|positive regulation of calcium ion transmembrane transport|
|negative regulation of ion transmembrane transporter activity|
|regulation of cardiac muscle contraction|
|regulation of release of sequestered calcium ion into cytosol|
|negative regulation of transporter activity|
|negative regulation of cation transmembrane transport|
|water-soluble vitamin metabolic process|
|regulation of calcium ion transmembrane transporter activity|
|regulation of striated muscle contraction|
|cellular oxidant detoxification|
|negative regulation of ion transmembrane transport|
|regulation of calcium-mediated signaling|
|regulation of calcium ion transport into cytosol|
|cellular detoxification|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|negative regulation of transmembrane transport|
|oxidoreductase activity|
|positive regulation of calcium ion transport|
|regulation of sequestering of calcium ion|
|vitamin metabolic process|
|detoxification|
|xenobiotic metabolic process|
|positive regulation of cation transmembrane transport|
|calcium-mediated signaling|
|negative regulation of ion transport|
|regulation of calcium ion transmembrane transport|
|positive regulation of ion transmembrane transport|
|regulation of muscle contraction|
|regulation of cation channel activity|
|sulfur compound biosynthetic process|
|cellular response to xenobiotic stimulus|
|monosaccharide metabolic process|
|positive regulation of transmembrane transport|
|cellular response to toxic substance|
|regulation of muscle system process|
|regulation of heart contraction|
|regulation of calcium ion transport|
|coenzyme metabolic process|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|response to xenobiotic stimulus|
|methylation|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|sulfur compound metabolic process|
|regulation of metal ion transport|
|cellular calcium ion homeostasis|
|cofactor metabolic process|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|carbohydrate metabolic process|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|negative regulation of intracellular signal transduction|
|response to toxic substance|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cytokine-mediated signaling pathway|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cellular homeostasis|
|carboxylic acid metabolic process|
|regulation of cellular localization|
|oxidation-reduction process|
|positive regulation of transport|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|response to cytokine|
|chemical homeostasis|
|negative regulation of molecular function|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|organonitrogen compound biosynthetic process|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.7|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.22|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.23|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|3.16|
|[[:results:exp433|LJH685 50μM R08 exp433]]|3.21|
|[[:results:exp518|RK-33 8μM R08 exp518]]|8.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9521
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GSTO1 Expression in NALM6 Cells: 5.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>