GSTO1

Gene Information

Official Symbol: GSTO1
Official Name: glutathione S-transferase omega 1
Aliases and Previous Symbols: N/A
Entrez ID: 9446
UniProt: P78417
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
UniProt Summary: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. {ECO:0000269|PubMed:10783391, ECO:0000269|PubMed:11511179, ECO:0000269|PubMed:17226937, ECO:0000269|PubMed:18028863, ECO:0000269|PubMed:21106529}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Milciclib 2μM R08 exp502	1.7
Lead acetate 2000μM R08 exp497	2.22
Ammonium tetrathiomolybdate 10μM R08 exp448	2.23
GSK-J4 1.5μM R08 exp441	3.16
LJH685 50μM R08 exp433	3.21
RK-33 8μM R08 exp518	8.5

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9521
Expression level (log2 read counts): 5.68

Expression Distribution

GST C
GST N

positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
methylarsonate reductase activity
glutathione dehydrogenase (ascorbate) activity
regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
regulation of skeletal muscle contraction by calcium ion signaling
positive regulation of ryanodine-sensitive calcium-release channel activity
L-ascorbic acid metabolic process
negative regulation of ryanodine-sensitive calcium-release channel activity
xenobiotic catabolic process
regulation of skeletal muscle contraction
negative regulation of release of sequestered calcium ion into cytosol
positive regulation of striated muscle contraction
positive regulation of sequestering of calcium ion
negative regulation of calcium ion transport into cytosol
cellular response to arsenic-containing substance
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
glutathione derivative biosynthetic process
glutathione derivative metabolic process
regulation of cardiac muscle contraction by calcium ion signaling
regulation of ryanodine-sensitive calcium-release channel activity
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
glutathione transferase activity
negative regulation of calcium-mediated signaling
response to arsenic-containing substance
negative regulation of calcium ion transmembrane transporter activity
negative regulation of calcium ion transmembrane transport
positive regulation of calcium ion transmembrane transporter activity
positive regulation of release of sequestered calcium ion into cytosol
negative regulation of cation channel activity
positive regulation of calcium-mediated signaling
positive regulation of muscle contraction
interleukin-12-mediated signaling pathway
cellular response to interleukin-12
response to interleukin-12
positive regulation of calcium ion transport into cytosol
negative regulation of calcium ion transport
positive regulation of cation channel activity
positive regulation of calcium ion transmembrane transport
negative regulation of ion transmembrane transporter activity
regulation of cardiac muscle contraction