GSX2

Entrez Summary: N/A
UniProt Summary: During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (By similarity). Transcription factor that binds 5'-CNAATTAG-3' DNA sequence. {ECO:0000250|UniProtKB:P31316}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Celastrol 0.12μM R05 exp225	-1.86
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.76

subpallium neuron fate commitment
forebrain dorsal/ventral pattern formation
forebrain morphogenesis
telencephalon regionalization
regulation of respiratory gaseous exchange by nervous system process
spinal cord association neuron differentiation
olfactory bulb interneuron differentiation
regulation of respiratory system process
dorsal spinal cord development
positive regulation of oligodendrocyte differentiation
regulation of respiratory gaseous exchange
subpallium development
forebrain regionalization
olfactory bulb development
brain morphogenesis
neuron fate specification
olfactory lobe development
regulation of oligodendrocyte differentiation
hindbrain morphogenesis
positive regulation of glial cell differentiation
forebrain neuron differentiation
positive regulation of Notch signaling pathway
cell differentiation in spinal cord
neuron fate commitment
forebrain generation of neurons
positive regulation of gliogenesis
regulation of glial cell differentiation
dorsal/ventral pattern formation
cell fate specification
regulation of Notch signaling pathway
spinal cord development
regulation of gliogenesis
hindbrain development
central nervous system neuron differentiation
cell fate commitment
telencephalon development
regionalization
forebrain development
sequence-specific DNA binding
pattern specification process