GTF2E2 [The Human Chemical-Genetic Interaction Map Project]

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======= GTF2E2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GTF2E2
  * **<color #00a2e8>Official Name</color>**: general transcription factor IIE subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2961|2961]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29084|P29084]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GTF2E2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GTF2E2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/189964|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The general transcription factor IIE (TFIIE) is part of the RNA polymerase II transcription initiation complex, recruiting TFIIH and being essential for promoter clearance by RNA polymerase II. TFIIE is a heterodimer (and sometimes heterotetramer) of alpha and beta subunits. The protein encoded by this gene represents the beta subunit of TFIIE. [provided by RefSeq, Jan 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. {ECO:0000269|PubMed:1956398, ECO:0000269|PubMed:1956404}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TFIIE beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcription factor TFIIE complex|
|TFIIH-class transcription factor complex binding|
|RNA polymerase II general transcription initiation factor activity|
|transcription factor TFIID complex|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|ncRNA transcription|
|transcription initiation from RNA polymerase II promoter|
|DNA-templated transcription, initiation|
|nuclear speck|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|DNA binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-2.03|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.91|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.71|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|2.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 271/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|15/28|
|blood|5/28|
|bone|11/25|
|breast|17/33|
|central nervous system|15/56|
|cervix|2/4|
|colorectal|7/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|7/15|
|kidney|8/21|
|liver|8/20|
|lung|28/75|
|lymphocyte|6/14|
|ovary|15/26|
|pancreas|6/24|
|peripheral nervous system|2/16|
|plasma cell|7/15|
|prostate|1/1|
|skin|9/24|
|soft tissue|1/7|
|thyroid|1/2|
|upper aerodigestive|7/22|
|urinary tract|14/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1168
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GTF2E2 Expression in NALM6 Cells: 4.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>