GTF2E2

Entrez Summary: The general transcription factor IIE (TFIIE) is part of the RNA polymerase II transcription initiation complex, recruiting TFIIH and being essential for promoter clearance by RNA polymerase II. TFIIE is a heterodimer (and sometimes heterotetramer) of alpha and beta subunits. The protein encoded by this gene represents the beta subunit of TFIIE. [provided by RefSeq, Jan 2017].
UniProt Summary: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. {ECO:0000269|PubMed:1956398, ECO:0000269|PubMed:1956404}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 271/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	15/28
blood	5/28
bone	11/25
breast	17/33
central nervous system	15/56
cervix	2/4
colorectal	7/17
esophagus	1/13
fibroblast	0/1
gastric	7/15
kidney	8/21
liver	8/20
lung	28/75
lymphocyte	6/14
ovary	15/26
pancreas	6/24
peripheral nervous system	2/16
plasma cell	7/15
prostate	1/1
skin	9/24
soft tissue	1/7
thyroid	1/2
upper aerodigestive	7/22
urinary tract	14/29
uterus	2/5

Expression Distribution

transcription factor TFIIE complex
TFIIH-class transcription factor complex binding
RNA polymerase II general transcription initiation factor activity
transcription factor TFIID complex
snRNA transcription by RNA polymerase II
snRNA transcription
ncRNA transcription
transcription initiation from RNA polymerase II promoter
DNA-templated transcription, initiation
nuclear speck
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
RNA binding
DNA binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression