GUCY1A3

Gene Information

Official Symbol: GUCY1A1
Official Name: guanylate cyclase 1 soluble subunit alpha 1
Aliases and Previous Symbols: N/A
Entrez ID: 2982
UniProt: Q02108
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15419
Expression level (log2 read counts): 4.52

Expression Distribution

Screen	Score
UMK57 1μM R01 exp59	-1.85
Rotenone 0.07μM R08 exp431	-1.77
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.71

Guanylate cyc
HNOBA
HNOB

retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
response to defense-related host nitric oxide production
response to defense-related nitric oxide production by other organism involved in symbiotic interaction
trans-synaptic signaling by soluble gas, modulating synaptic transmission
retrograde trans-synaptic signaling by soluble gas
guanylate cyclase complex, soluble
trans-synaptic signaling by nitric oxide, modulating synaptic transmission
retrograde trans-synaptic signaling by nitric oxide
synaptic signaling by nitric oxide
trans-synaptic signaling by nitric oxide
trans-synaptic signaling by soluble gas
positive regulation of nitric oxide mediated signal transduction
response to host immune response
response to immune response of other organism involved in symbiotic interaction
response to defenses of other organism involved in symbiotic interaction
response to host
retrograde trans-synaptic signaling
response to host defenses
relaxation of vascular smooth muscle
relaxation of smooth muscle
guanylate cyclase activity
regulation of nitric oxide mediated signal transduction
cGMP biosynthetic process
trans-synaptic signaling, modulating synaptic transmission
negative regulation of smooth muscle contraction
cGMP metabolic process
nitric oxide mediated signal transduction
relaxation of muscle
cyclic nucleotide biosynthetic process
negative regulation of muscle contraction
cyclic purine nucleotide metabolic process
vasodilation
cyclic nucleotide metabolic process
positive regulation of blood vessel diameter
regulation of smooth muscle contraction
GABA-ergic synapse
regulation of blood vessel diameter
regulation of tube diameter
regulation of tube size
heme binding