GYS2 [The Human Chemical-Genetic Interaction Map Project]

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======= GYS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GYS2
  * **<color #00a2e8>Official Name</color>**: glycogen synthase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2998|2998]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P54840|P54840]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GYS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GYS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138571|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene, liver glycogen synthase, catalyzes the rate-limiting step in the synthesis of glycogen - the transfer of a glucose molecule from UDP-glucose to a terminal branch of the glycogen molecule. Mutations in this gene cause glycogen storage disease type 0 (GSD-0) - a rare type of early childhood fasting hypoglycemia with decreased liver glycogen content. [provided by RefSeq, Dec 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glycogen syn|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ectoplasm|
|glycogen (starch) synthase activity|
|glycogen synthase activity, transferring glucose-1-phosphate|
|glycogen biosynthetic process|
|glucan biosynthetic process|
|polysaccharide biosynthetic process|
|cellular polysaccharide biosynthetic process|
|glycogen metabolic process|
|cellular glucan metabolic process|
|glucan metabolic process|
|cortical actin cytoskeleton|
|cellular carbohydrate biosynthetic process|
|energy reserve metabolic process|
|cellular polysaccharide metabolic process|
|polysaccharide metabolic process|
|carbohydrate biosynthetic process|
|cell cortex|
|response to glucose|
|response to hexose|
|response to monosaccharide|
|cellular carbohydrate metabolic process|
|response to carbohydrate|
|energy derivation by oxidation of organic compounds|
|cytoskeleton|
|generation of precursor metabolites and energy|
|carbohydrate metabolic process|
|protein homodimerization activity|
|oxidation-reduction process|
|response to oxygen-containing compound|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.11|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-2|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16456
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GYS2 Expression in NALM6 Cells: -1.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>