GZMA

Entrez Summary: Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008].
UniProt Summary: Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12524539, ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of endodeoxyribonuclease activity
negative regulation of deoxyribonuclease activity
negative regulation of nuclease activity
regulation of endodeoxyribonuclease activity
regulation of deoxyribonuclease activity
regulation of nuclease activity
cytolysis
negative regulation of oxidoreductase activity
immunological synapse
negative regulation of DNA binding
regulation of oxidoreductase activity
negative regulation of DNA metabolic process
regulation of DNA binding
serine-type endopeptidase activity
negative regulation of binding
regulation of DNA metabolic process
regulation of binding
negative regulation of hydrolase activity
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
positive regulation of apoptotic process
positive regulation of programmed cell death
protein catabolic process
response to bacterium
positive regulation of cell death
negative regulation of catalytic activity
protein homodimerization activity
cellular macromolecule catabolic process
apoptotic process
macromolecule catabolic process
programmed cell death
organonitrogen compound catabolic process
cell death
negative regulation of molecular function
proteolysis
regulation of hydrolase activity
response to other organism
response to external biotic stimulus
response to biotic stimulus
negative regulation of nucleobase-containing compound metabolic process