H2AFY

Gene Information

Official Symbol: MACROH2A1
Official Name: macroH2A.1 histone
Aliases and Previous Symbols: N/A
Entrez ID: 9555
UniProt: O75367
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription (PubMed:12718888, PubMed:15621527, PubMed:16428466). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation (PubMed:15897469). Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (PubMed:12718888, PubMed:16428466). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (PubMed:16428466, PubMed:16107708). {ECO:0000269|PubMed:12718888, ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:16107708, ECO:0000269|PubMed:16428466}. Isoform 2: Represses SOD3 gene expression. {ECO:0000269|PubMed:23022728}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17178
Expression level (log2 read counts): 8.83

Expression Distribution

Screen	Score
BI-6727 0.04μM R03 exp98	-2.04
Alda-1 10μM R06 exp262	1.87

Macro
Histone

negative regulation of protein localization to chromosome, telomeric region
negative regulation of histone phosphorylation
negative regulation of transcription of nucleolar large rRNA by RNA polymerase I
regulation of chromatin silencing at rDNA
positive regulation of maintenance of sister chromatid cohesion
positive regulation of maintenance of mitotic sister chromatid cohesion
rDNA binding
negative regulation of histone H3-K27 methylation
double-stranded methylated DNA binding
negative regulation of histone H3-K4 methylation
negative regulation of transcription by RNA polymerase I
Barr body
sex chromatin
regulation of maintenance of mitotic sister chromatid cohesion
regulation of maintenance of sister chromatid cohesion
establishment of protein localization to chromatin
protein serine/threonine kinase inhibitor activity
positive regulation of sister chromatid cohesion
regulation of histone H3-K27 methylation
regulation of histone phosphorylation
regulation of transcription of nucleolar large rRNA by RNA polymerase I
regulation of protein localization to chromosome, telomeric region
pericentric heterochromatin
establishment of protein localization to chromosome
positive regulation of keratinocyte differentiation
positive regulation of mitotic sister chromatid segregation
dosage compensation
negative regulation of histone methylation
regulation of sister chromatid cohesion
protein localization to chromatin
positive regulation of epidermal cell differentiation
regulation of histone H3-K4 methylation
condensed chromosome
nuclear chromosome
positive regulation of chromosome segregation
regulation of transcription by RNA polymerase I
RNA polymerase II core promoter sequence-specific DNA binding
regulation of chromatin silencing
positive regulation of epidermis development
negative regulation of histone modification