H2AFY2 [The Human Chemical-Genetic Interaction Map Project]

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======= H2AFY2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MACROH2A2
  * **<color #00a2e8>Official Name</color>**: macroH2A.2 histone
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55506|55506]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P0M6|Q9P0M6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=H2AFY2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20H2AFY2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616141|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation. {ECO:0000269|PubMed:15621527}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Macro|
|Histone|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of transcription of nucleolar large rRNA by RNA polymerase I|
|negative regulation of transcription by RNA polymerase I|
|Barr body|
|establishment of protein localization to chromatin|
|regulation of transcription of nucleolar large rRNA by RNA polymerase I|
|establishment of protein localization to chromosome|
|positive regulation of keratinocyte differentiation|
|dosage compensation|
|protein localization to chromatin|
|positive regulation of epidermal cell differentiation|
|regulation of transcription by RNA polymerase I|
|positive regulation of epidermis development|
|regulation of keratinocyte differentiation|
|positive regulation of epithelial cell differentiation|
|regulation of epidermal cell differentiation|
|protein localization to chromosome|
|nucleosome|
|chromatin DNA binding|
|negative regulation of gene expression, epigenetic|
|regulation of epidermis development|
|nuclear chromosome, telomeric region|
|nucleosome assembly|
|chromatin assembly|
|regulation of epithelial cell differentiation|
|chromatin assembly or disassembly|
|nucleosome organization|
|DNA packaging|
|protein-DNA complex assembly|
|transcription regulatory region DNA binding|
|regulation of gene expression, epigenetic|
|nuclear chromatin|
|protein-DNA complex subunit organization|
|DNA conformation change|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|establishment of protein localization to organelle|
|protein heterodimerization activity|
|chromatin organization|
|protein localization to organelle|
|brain development|
|head development|
|cellular protein-containing complex assembly|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of cell differentiation|
|central nervous system development|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.72|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.563|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7356
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='H2AFY2 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>