H2AFY2

Entrez Summary: N/A
UniProt Summary: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation. {ECO:0000269|PubMed:15621527}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Ribavirin 10 to 15μM on day4 R04 exp160	1.72
GSK591 2.6μM R03 exp128	1.83

Macro
Histone

negative regulation of transcription of nucleolar large rRNA by RNA polymerase I
negative regulation of transcription by RNA polymerase I
Barr body
establishment of protein localization to chromatin
regulation of transcription of nucleolar large rRNA by RNA polymerase I
establishment of protein localization to chromosome
positive regulation of keratinocyte differentiation
dosage compensation
protein localization to chromatin
positive regulation of epidermal cell differentiation
regulation of transcription by RNA polymerase I
positive regulation of epidermis development
regulation of keratinocyte differentiation
positive regulation of epithelial cell differentiation
regulation of epidermal cell differentiation
protein localization to chromosome
nucleosome
chromatin DNA binding
negative regulation of gene expression, epigenetic
regulation of epidermis development
nuclear chromosome, telomeric region
nucleosome assembly
chromatin assembly
regulation of epithelial cell differentiation
chromatin assembly or disassembly
nucleosome organization
DNA packaging
protein-DNA complex assembly
transcription regulatory region DNA binding
regulation of gene expression, epigenetic
nuclear chromatin
protein-DNA complex subunit organization
DNA conformation change
RNA polymerase II regulatory region sequence-specific DNA binding
establishment of protein localization to organelle
protein heterodimerization activity
chromatin organization
protein localization to organelle
brain development
head development