HACE1

Official Symbol: HACE1
Official Name: HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
Aliases and Previous Symbols: N/A
Entrez ID: 57531
UniProt: Q8IYU2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: This gene encodes a HECT domain and ankyrin repeat-containing ubiquitin ligase. The encoded protein is involved in specific tagging of target proteins, leading to their subcellular localization or proteasomal degradation. The protein is a potential tumor suppressor and is involved in the pathophysiology of several tumors, including Wilm's tumor. [provided by RefSeq, Mar 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Rac protein signal transduction
protein K48-linked ubiquitination
Rac GTPase binding
Golgi cisterna membrane
membrane fusion
Golgi organization
Rab GTPase binding
ubiquitin protein ligase activity
ubiquitin-protein transferase activity
Ras protein signal transduction
nuclear body
protein polyubiquitination
small GTPase mediated signal transduction
endomembrane system organization
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
Golgi membrane
protein catabolic process
protein ubiquitination
protein modification by small protein conjugation
regulation of cell migration
membrane organization
cellular macromolecule catabolic process
regulation of cell motility
regulation of locomotion
protein modification by small protein conjugation or removal
regulation of cellular component movement
endoplasmic reticulum
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
cell cycle
intracellular signal transduction
organic substance catabolic process
cellular catabolic process