HADH [The Human Chemical-Genetic Interaction Map Project]

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======= HADH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HADH
  * **<color #00a2e8>Official Name</color>**: hydroxyacyl-CoA dehydrogenase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3033|3033]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16836|Q16836]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HADH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HADH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601609|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|3HCDH|
|3HCDH N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|3-hydroxyacyl-CoA dehydrogenase activity|
|NAD+ binding|
|negative regulation of insulin secretion|
|negative regulation of peptide hormone secretion|
|fatty acid beta-oxidation|
|negative regulation of hormone secretion|
|response to activity|
|fatty acid oxidation|
|lipid oxidation|
|fatty acid catabolic process|
|positive regulation of cold-induced thermogenesis|
|monocarboxylic acid catabolic process|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|regulation of cold-induced thermogenesis|
|regulation of insulin secretion|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|cellular lipid catabolic process|
|lipid modification|
|negative regulation of secretion by cell|
|regulation of peptide hormone secretion|
|response to insulin|
|negative regulation of secretion|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|regulation of hormone secretion|
|lipid catabolic process|
|fatty acid metabolic process|
|mitochondrial matrix|
|response to peptide hormone|
|small molecule catabolic process|
|regulation of protein secretion|
|response to peptide|
|negative regulation of transport|
|regulation of peptide secretion|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|response to hormone|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|regulation of protein localization|
|response to nitrogen compound|
|lipid metabolic process|
|mitochondrion|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2.93|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.01|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-2|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.97|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.75|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.74|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-1.73|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|1.87|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.98|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15981
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HADH Expression in NALM6 Cells: 6.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>