HADH

Entrez Summary: This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15. [provided by RefSeq, May 2010].
UniProt Summary: Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

3HCDH
3HCDH N

3-hydroxyacyl-CoA dehydrogenase activity
NAD+ binding
negative regulation of insulin secretion
negative regulation of peptide hormone secretion
fatty acid beta-oxidation
negative regulation of hormone secretion
response to activity
fatty acid oxidation
lipid oxidation
fatty acid catabolic process
positive regulation of cold-induced thermogenesis
monocarboxylic acid catabolic process
negative regulation of protein secretion
negative regulation of peptide secretion
regulation of cold-induced thermogenesis
regulation of insulin secretion
negative regulation of protein transport
negative regulation of establishment of protein localization
cellular lipid catabolic process
lipid modification
negative regulation of secretion by cell
regulation of peptide hormone secretion
response to insulin
negative regulation of secretion
organic acid catabolic process
carboxylic acid catabolic process
regulation of hormone secretion
lipid catabolic process
fatty acid metabolic process
mitochondrial matrix
response to peptide hormone
small molecule catabolic process
regulation of protein secretion
response to peptide
negative regulation of transport
regulation of peptide secretion
monocarboxylic acid metabolic process
regulation of hormone levels
regulation of protein transport
regulation of peptide transport