HBZ [The Human Chemical-Genetic Interaction Map Project]

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======= HBZ =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HBZ
  * **<color #00a2e8>Official Name</color>**: hemoglobin subunit zeta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3050|3050]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02008|P02008]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HBZ&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HBZ|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142310|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Globin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|haptoglobin binding|
|organic acid binding|
|haptoglobin-hemoglobin complex|
|hemoglobin complex|
|oxygen carrier activity|
|erythrocyte maturation|
|oxygen transport|
|gas transport|
|hydrogen peroxide catabolic process|
|oxygen binding|
|erythrocyte development|
|peroxidase activity|
|hydrogen peroxide metabolic process|
|antibiotic catabolic process|
|myeloid cell development|
|cofactor catabolic process|
|erythrocyte differentiation|
|erythrocyte homeostasis|
|cellular oxidant detoxification|
|cellular detoxification|
|antibiotic metabolic process|
|myeloid cell homeostasis|
|reactive oxygen species metabolic process|
|detoxification|
|iron ion binding|
|anatomical structure maturation|
|heme binding|
|drug catabolic process|
|drug transport|
|cell maturation|
|homeostasis of number of cells|
|cellular response to toxic substance|
|myeloid cell differentiation|
|developmental maturation|
|cofactor metabolic process|
|drug metabolic process|
|response to toxic substance|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|negative regulation of transcription by RNA polymerase II|
|response to drug|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|homeostatic process|
|cell development|
|negative regulation of gene expression|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3706
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HBZ Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>