HCN4

Gene Information

Official Symbol: HCN4
Official Name: hyperpolarization activated cyclic nucleotide gated potassium channel 4
Aliases and Previous Symbols: N/A
Entrez ID: 10021
UniProt: Q9Y3Q4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008].
UniProt Summary: Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli. {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953, ECO:0000269|PubMed:16407510, ECO:0000269|PubMed:19165230, ECO:0000269|PubMed:20829353}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14990
Expression level (log2 read counts): -2.6

Expression Distribution

Screen	Score
5-Fluorouracil 2μM R00 exp1	-1.8
Ammonium tetrathiomolybdate 10μM R08 exp448	1.89

cNMP binding
Ion trans
Ion trans N

voltage-gated potassium channel activity involved in SA node cell action potential depolarization
HCN channel complex
membrane depolarization during SA node cell action potential
cellular response to cGMP
response to cGMP
regulation of cardiac muscle cell action potential involved in regulation of contraction
SA node cell to atrial cardiac muscle cell signaling
SA node cell action potential
SA node cell to atrial cardiac muscle cell communication
intracellular cAMP-activated cation channel activity
sodium ion import across plasma membrane
membrane depolarization during cardiac muscle cell action potential
voltage-gated sodium channel activity
cAMP binding
cell-cell signaling involved in cardiac conduction
regulation of cardiac muscle cell action potential
membrane depolarization during action potential
intrinsic component of plasma membrane
regulation of heart rate by cardiac conduction
regulation of cardiac muscle cell contraction
regulation of actin filament-based movement
potassium ion import across plasma membrane
regulation of membrane depolarization
cell communication involved in cardiac conduction
regulation of action potential
cardiac muscle cell action potential
membrane depolarization
cellular response to cAMP
voltage-gated potassium channel activity
inorganic cation import across plasma membrane
inorganic ion import across plasma membrane
regulation of cardiac muscle contraction
sodium ion transmembrane transport
regulation of striated muscle contraction
cardiac conduction
action potential
import across plasma membrane
regulation of heart rate
response to cAMP
multicellular organismal signaling