HDAC10

Entrez Summary: The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
UniProt Summary: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

acetylputrescine deacetylase activity
spermidine deacetylation
polyamine deacetylation
acetylspermidine deacetylase activity
positive regulation of mismatch repair
regulation of mismatch repair
peptidyl-lysine deacetylation
spermidine metabolic process
protein deacetylase activity
deacetylase activity
polyamine metabolic process
histone deacetylase activity
histone deacetylase complex
oligodendrocyte development
histone deacetylation
protein deacetylation
homologous recombination
cellular biogenic amine metabolic process
cellular amine metabolic process
protein deacylation
macromolecule deacylation
positive regulation of DNA repair
amine metabolic process
oligodendrocyte differentiation
positive regulation of response to DNA damage stimulus
glial cell development
histone deacetylase binding
regulation of DNA repair
macroautophagy
glial cell differentiation
ammonium ion metabolic process
positive regulation of DNA metabolic process
gliogenesis
regulation of response to DNA damage stimulus
DNA recombination
autophagy
process utilizing autophagic mechanism
peptidyl-lysine modification
enzyme binding
regulation of DNA metabolic process